During pregnancy, fetal DNA travels from the placenta to the mother’s blood stream and circulates along with her own DNA. VERACITY is a new generation non-invasive prenatal test that accurately measures the fetal cell-free DNA in the maternal blood to detect the presence of fetal aneuploidies and microdeletions. VERACITY has been validated for both single and twin pregnancies as well as pregnancies conceived through in-vitro fertilization (IVF).

The doctor or lab collects a blood sample from the mother’s arm and sends it to our state-of-the-art laboratories for analysis. At the laboratory, cell-free DNA is isolated from the mother’s blood and analyzed using our proprietary, new generation analytic and bioinformatic technology. Results are provided to your doctor in a few working days.

NEW GENERATION NON-INVASIVE PRENATAL TEST (NIPT)

  • Can be done from 10 weeks of pregnancy
  • Validated for singleton and twin pregnancies
  • Applicable also for IVF pregnancies
  • Preferred for its accuracy, robustness and affordability
What is Veracity?

PROPRIETARY TARGETED METHODOLOGY

VERACITY is a new generation non-invasive prenatal test (NIPT) for the detection of fetal chromosomal aneuploidies and microdeletions. It uses proprietary technology based on cutting-edge research and development in molecular genetics and bioinformatics. It was specifically designed by NIPD Genetics to avoid technical limitations and shortcomings of other NIPT.

VERACITY has been developed by an outstanding scientific team with over 25 years of experience in the field of prenatal diagnosis, molecular medicine, genomics, transcriptomics, methylomics and bioinformatics.

VERACITY uses novel Targeted Enrichment Technology that enables with unparalleled accuracy chromosomal aneuploidy detection as well as fetal fraction measurement. Targeted regions on selected chromosomes and chromosomal regions are captured, enriched and analysed for the detection of aneuploidies and microdeletions using our proprietary genomic and bioinformatic technologies.

Veracity
Conventional
Prenatal Tests
Cell-free DNA extracted from maternal plasma
Screening combines... Biochemical Screening Results, Ultrasound Findings and Other Parameters
Highly Accurate >99% detection rate
Low Accuracy Risk score has 80–95% detection rate
Safe No risk of fetal miscarriage
Risk for miscarriage through amniocentesis or CVS (0.5%)
Fast Can be done from 10 weeks Results in 4-7 working days
Can be done after 12 weeks of pregnancy
First Trimester
Screening
Invasive
Prenatal Diagnosis
Type of Test
Screening that measures likelihood of trisomies 21, 18 and 13, and X, Y aneuploidies, and four microdeletions. Screening test that measures likelihood of trisomies 21, 18, and 13. Diagnostic test to determine chromosome abnormalities.
Method
Blood draw from 10th week of pregnancy. Blood draw and ultrasound between 11th and 14th weeks of pregnancy.

CVS: Chorionic villus sampling between 10th and 12th weeks of pregnancy.

Amniocentesis: Sampling of amniotic fluid using a needle through the abdomen between 15th and 20th weeks of pregnancy.

Risks
Safe. No risks to mother or child. Safe. No risks to mother or child. About 0.5% risk of fetal loss because of inherent invasiveness of the procedure used to obtain fetal material.
Accuracy
Higher than 99% for trisomy 21, 18 and 13 and several other anomalies. 80-95% for trisomy 21, 18 and 13. Higher than 99% for trisomy 21, 18 and 13 and several other anomalies.

UNIQUE FEATURES OF VERACITY

TARGETED GENOMIC ANALYSIS

VERACITY uses proprietary technology, specifically designed to avoid genomic regions with complex architecture that affect test performance. This overcomes problems associated with other NIPTs and increases the precision and accuracy of VERACITY.

HIGH READ DEPTH

Read-depth is the number of times a nucleotide in the genome is read during analysis. VERACITY captures DNA fragments from targeted regions on chromosomes of interest. So, it is able to read these selected regions at an extremely high read-depth which improves the statistical accuracy of the analysis and increases the sensitivity and specificity of VERACITY.

FETAL FRACTION MEASUREMENT

A proprietary bioinformatics software accurately calculates fetal fraction. Accurate fetal fraction measurement increases the robustness and reliability of VERACITY.

MULTI-ENGINE ANALYSIS PIPELINES

Proprietary bioinformatics pipelines analyze the sequencing data produced from each test. This multi-engine analysis increases the sensitivity and specificity of aneuploidy, microdeletion and fetal gender detection. Infographic for this also needs to be changed.

WHAT DOES VERACITY TEST FOR?

AUTOSOMAL ANEUPLOIDIES

  • Down syndrome (Trisomy 21)
  • Edwards syndrome (Trisomy 18)
  • Patau syndrome (Trisomy 13)

SEX CHROMOSOME ANEUPLOIDIES

  • Turner syndrome (Monosomy X)
  • Triple X syndrome (Trisomy X)
  • Klinefelter syndrome (XXY)
  • Jacobs syndrome (XYY)
  • XXYY syndrome

MICRODELETIONS

  • DiGeorge syndrome (22q11.2)
  • 1p36 deletion syndrome
  • Smith-Magenis syndrome (17p11.2)
  • Wolf-Hirschhorn syndrome (4p16.3)

CLINICAL PERFORMANCE

AUTOSOMAL TRISOMIES

KARYOTYPE Number Follow-Up Correct SPECIFICITY NPV
Normal 10280 10280 10280 99.98% (99.93-99.998%) 100% (99.96 – 100%)
KARYOTYPE Number Follow-Up Correct SENSITIVITY PPV
Trisomy 21 144 45 45 100% (92 – 100%) 100% (92 – 100%)
Trisomy 18 30 11 11 100% (69 – 100%) 100% (69 – 100%)
Trisomy 13 16 7 5 100% (48 – 100%) 71% (29 – 96%)

SEX CHROMOSOME ANEUPLOIDIES

KARYOTYPE Number Follow-Up Correct SPECIFICITY NPV
Normal 6200 6200 6200 99.95% (99.86 – 99.99%) 100% (99.94 – 100%)
KARYOTYPE Number Follow-Up Correct SENSITIVITY PPV
45, X 16 7 4 100% (40-100%) 57% (18-90%)
47, XXX 6 2 2 - -
47, XXY 10 4 4 - -
47, XYY 3 0 - - -
48, XXYY 1 1 1 - -

VALIDATION STUDIES

  • Development and Validation Study 1
    Number of Samples Correct Call Confidence Interval
    Normal 538 538 (100%) 99.9 — 100
    T21 52 52 (100%) 93.2 — 100
    T18 16 16 (100%) 79.4 — 100
    T13 5 5 (100%) 47.8 — 100
    Male 244 244 (100%) 99.9 — 100
  • Independent Validation Study 2
    Number of Samples Correct Call Confidence Interval
    Normal 73 73 (100%) 95.1 — 100
    T21 24 24 (100%) 85.8 — 100
  • Sex Chromosome Aneuploidies Validation Study 3
    Number of Samples Correct Call Confidence Interval
    Normal 286 286 (100%) 99.9 — 100
    Sex Chromosome
    Aneuploidies
    14 14 (100%) 93.2 — 100
  1. George Koumbaris, Elena Kypri, Kyriakos Tsangaras, Achilleas Achilleos, Petros Mina, Maria Neofytou, et al., and Philippos C Patsalis Cell-free DNA analysis of targeted genomic regions in maternal plasma for non-invasive prenatal testing of trisomy 21, trisomy 18, trisomy 13 and fetal sex. Clinical Chemistry 62:6, 848-855, 2016
  2. Manuscript under review.
  3. Manuscript under review.

Other Products

NIPD Genetics - Privacy Policy

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This Privacy Policy applies only to www.nipd.com and its subdomains (hereafter collectively referred to as “Sites") that link to this policy. NIPD Genetics Sites are owned by NIPD Genetics Public Company Ltd and are operated by NIPD Genetics Public Company Ltd and on occasion by a third-party that is responsible for the technical maintenance of the Sites.

If, you do not agree with this Privacy Policy, please do not access or use any of NIPD Genetics Sites.

NIPD Genetics values your interest in NIPD Genetics, its products and its services. NIPD Genetics takes the protection of your data seriously.

Personal data for purposes of this Privacy Policy, is any information by which you can be individually identified, including, but not limited to, your name, profession, address, e-mail address, and telephone number.

You may contact NIPD Genetics Public Company Ltd at
NIPD Genetics Public Company Ltd
Neas Engomis 31
Engomi, Nicosia
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NIPD Genetics Data Protection Officer can be reached at dpo@nipd.com

This Privacy Policy applies only to the Sites as defined above and which are operated by NIPD Genetics. The NIPD Genetics Privacy Policy seeks to inform the users of its Sites of the following:

NIPD Genetics will not use or share your information with anyone, except as described in this Privacy Policy. This Privacy Policy does not apply to any information we might collect by other digital and offline means and or from other digital and offline sources. The use of information collected through our Sites shall be limited to the purposes under this Privacy Policy and our Terms of Use to customers.

This page informs you of our policies regarding the collection, use, and disclosure of personal data when you use our Sites and the choices you have associated with that data.

We use your data to provide and improve the Sites. By using the Sites, you agree to the collection and use of information in accordance with this policy. Unless otherwise defined in this Privacy Policy, terms used in this Privacy Policy have the same meanings as in our Terms and Conditions, accessible from www.nipd.com

Type of personal information NIPD Genetics may collect through its Sites

Information Collection And Use

We collect several different types of information for various purposes to provide and improve our Sites and services to you.

Personal Data

While using NIPD Genetics Sites, you may be asked to provide NIPD Genetics certain personally identifiable information that can be used to contact or identify you ("Personal Information"). Personal Information that might be used to identify you includes, but is not limited to:

If you send us a query via our Contact us form, your email address, the content and any follow up emails are retained indefinitely.

Cookies and Usage Data

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We may also collect information how the Sites are accessed and used ("Usage Data"). This Usage Data may include information such as your computer's Internet Protocol address (e.g. IP address), browser type, browser version, the pages of our Sites that you visit, the time and date of your visit, the time spent on those pages, unique device identifiers and other diagnostic data.

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Your information, including personal data, may be transferred to — and maintained on — computers located outside of your province, country or other governmental jurisdiction where the data protection laws may differ than those from your jurisdiction.

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Your consent to this Privacy Policy followed by your submission of such information represents your agreement to that transfer.

www.nipd.com will take all reasonable steps necessary to ensure that your data is treated securely and in accordance with this Privacy Policy and no transfer of your personal data will take place to an organization or a country unless there are adequate controls in place including the security of your data and other personal information.

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NIPD Genetics complies with the protection of personal data regulation and will not sale or trade your personal data.

NIPD Genetics may disclose your personal data in the good faith belief that such action is necessary to:

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The security of your data is important to us, but remember that no method of transmission over the Internet, or method of electronic storage is 100% secure. While we strive to use commercially acceptable means to protect your Personal Data, we cannot guarantee its absolute security.

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We may employ third party companies and individuals to facilitate, maintain or operate our Sites ("Service Providers"), to provide the SItes on our behalf, to perform service-related services or to assist us in analyzing how our Sites is used.

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We may use third-party Service Providers to monitor and analyze the use of our Sites.

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Google Analytics is a web analytics service offered by Google that tracks and reports website traffic. Google uses the data collected to track and monitor the use of our Service. This data is shared with other Google services. Google may use the collected data to contextualize and personalize the ads of its own advertising network.

You can opt-out of having made your activity on the Service available to Google Analytics by installing the Google Analytics opt-out browser add-on. The add-on prevents the Google Analytics JavaScript (ga.js, analytics.js, and dc.js) from sharing information with Google Analytics about visits activity.

For more information on the privacy practices of Google, please visit the Google Privacy & Terms web page

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You have the right to review, update or delete any of your personal data by sending a request at NIPD Genetics Personal Data Officer pdo@nipd.com

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We have no control over and assume no responsibility for the content, privacy policies or practices of any third-party sites or services.

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Our Service does not address anyone under the age of 18 ("Children").

We do not knowingly collect personally identifiable information from anyone under the age of 18. If you are a parent or guardian and you are aware that your Children has provided us with Personal Data, please contact us. If we become aware that we have collected Personal Data from children without verification of parental consent, we take steps to remove that information from our servers.

Changes to This Privacy Policy

We may update our Privacy Policy from time to time. We will notify you of any changes by posting the new Privacy Policy on this page.

We will let you know via email and/or a prominent notice on our Service, prior to the change becoming effective and update the "effective date" at the top of this Privacy Policy.

You are advised to review this Privacy Policy periodically for any changes. Changes to this Privacy Policy are effective when they are posted on this page.

Contact Us

If you have any questions about this Privacy Policy, please contact pdo@nipd.com

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