ForeSENTIA is an extensive portfolio of tumor profile panels that identify genetic alterations (changes) implicated in cancer. The ForeSENTIA panels test for alterations on genes that have important roles in cancer. Identifying these genetic alterations is beneficial for:

  • providing an in-depth understanding of the molecular profile to the healthcare provider
  • giving a better prognostic assessment
  • allowing for more precise and effective medical recommendations
  • improving clinical management and patient outcome
  • guiding therapy options

ForeSENTIA has 2 panel categories – depending on your cancer type and its characteristics, your doctor will recommend the best panel for you.

COMPREHENSIVE TUMOR PROFILE PANELS

ForeSENTIA comprehensive tumor profile panels focus on a number of genetic changes found in specific cancer types.

  • BREAST / OVARIAN

    44

  • COLORECTAL

    33

  • LUNG (NSCLC)

    35

  • PROSTATE

    27

  • MELANOMA

    21

  • GLIOMA

    22*

  • PAN-CANCER

    76*

* 1p/19q codeletion is also tested in these panels and reported only in the context of glioma diagnosis.

BREAST/OVARIAN TUMOR PROFILE PANEL

Description

The ForeSENTIA breast/ovarian tumor profile panel tests for numerous genetic alterations that are frequently found in breast or ovarian tumors. Identifying the genetic alterations that have led to cancer development can empower the healthcare provider with clinically actionable and therapeutic information and allow them to tailor medical treatment to each tumor’s unique characteristics.

Who is this test for?

Any patient diagnosed with breast or ovarian cancer can have tumor profile testing with the ForeSENTIA breast/ovarian panel to help identify the specific genetic alterations that are associated with their tumor.

Number Of Genes Tested

44

Sample: Unstained sections from tumor biopsy sample

Turnaround time: 2-3 Weeks

Genes Tested

The table below shows the genes tested by the ForeSENTIA beast/ovarian tumor profile panel, and whether the genes examined are tested for Single Nucleotide Variants, Insertions and Deletions, Copy Number Alterations, Translocations or a combination of variants.

ForeSENTIA Breast/Ovarian Tumor Profile Panel

Single Nucleotide Variants / Insertions and Deletions Copy Number Alterations Translocations
AKT1, ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CHEK2, CTNNB1, DICER1, EGFR, ERBB2, ERBB3, ESR1, FBXW7, FOXA1, FOXL2, GATA3, KIT, KRAS, MAP3K1, MRE11A, MTOR, NBN, NRAS, PALB2, PIK3CA, PIK3CB, POLE, PTEN, RAD51C, RAD51D, RAF1, RET, RUNX1, SMAD4, TP53 EGFR, ERBB2, ESR1, FGFR1, FGFR2, FGFR3, KRAS, MET, PIK3CA, PTEN, TP53 NTRK1, NTRK2, NTRK3

COLORECTAL TUMOR PROFILE PANEL

Description

The ForeSENTIA colorectal tumor profile panel tests for numerous genetic alterations that are frequently found in colorectal tumors. Identifying the genetic alterations that have led to cancer development can empower the healthcare provider with clinically actionable and therapeutic information and allow them to tailor medical treatment to each tumor’s unique characteristics.

Who is this test for?

Any patient diagnosed with colorectal cancer can have tumor profile testing with the ForeSENTIA colorectal cancer panel to help identify the specific genetic alterations that are associated with their tumor.

Number Of Genes Tested

33

Sample: Unstained sections from tumor biopsy sample

Turnaround time: 2-3 Weeks

Genes Tested

The table below shows the genes tested by the ForeSENTIA colorectal tumor profile panel, and whether the genes examined are tested for Single Nucleotide Variants, Insertions and Deletions, Copy Number Alterations, Translocations or a combination of variants.

ForeSENTIA Colorectal Tumor Profile Panel

Single Nucleotide Variants / Insertions and Deletions Copy Number Alterations Translocations
AKT1, APC, ATM, BRAF, BRCA1, BRCA2, CTNNB1, EGFR, ERBB2, FBXW7, GNAS, KRAS, MLH1, MSH2, MSH6, MTOR, NRAS, NTRK1, PALB2, PIK3CA, PIK3CB, PMS2, POLE, PTEN, RAF1, SMAD4, TP53 EGFR, ERBB2, FGFR1, FGFR2, FGFR3, KRAS, MET, TP53 NTRK1, NTRK2, NTRK3

LUNG (NSCLC) TUMOR PROFILE PANEL

Description

The ForeSENTIA lung (NSCLC) tumor profile panel tests for numerous genetic alterations that are frequently found in lung (Non Small Cell Lung Cancers – NSCLC) tumors. Identifying the genetic alterations that have led to cancer development can empower the healthcare provider with clinically actionable and therapeutic information and allow them to tailor medical treatment to each tumor’s unique characteristics.

Who is this test for?

Any patient diagnosed with lung (NSCLC) cancer can have tumor profile testing with the ForeSENTIA lung (NSCLC) panel to help identify the specific genetic alterations that are associated with their tumor.

Number Of Genes Tested

35

Sample: Unstained sections from tumor biopsy sample

Turnaround time: 2-3 Weeks

Genes Tested

The table below shows the genes tested by the ForeSENTIA lung (NSCLC) tumor profile panel, and whether the genes examined are tested for Single Nucleotide Variants, Insertions and Deletions, Copy Number Alterations, Translocations or a combination of variants.

ForeSENTIA Lung (NSCLC) Tumor Profile Panel

Single Nucleotide Variants / Insertions and Deletions Copy Number Alterations Translocations
AKT1, ALK, APC, ARAF, ATM,BRAF, BRCA2, CTNNB1, DDR2, EGFR, ERBB2, ERBB3, ERBB4, FBXW7, JAK2, KEAP1, KRAS, MAP2K1, MET, NRAS, PIK3CA, POLE, PTEN, RAF1, SMAD4, STK11, TP53 EGFR, ERBB2, FGFR1, FGFR2, FGFR3, MET, PIK3CA, PTEN, TP53 ALK, FGFR3, NTRK1, NTRK2, NTRK3, RET, ROS1

MELANOMA TUMOR PROFILE PANEL

Description

The ForeSENTIA melanoma tumor profile panel tests for numerous genetic alterations that are frequently found in melanomas. Identifying the genetic alterations that have led to cancer development can empower the healthcare provider with clinically actionable and therapeutic information and allow them to tailor medical treatment to each tumor’s unique characteristics.

Who is this test for?

Any patient diagnosed with melanoma cancer can have tumor profile testing with the ForeSENTIA melanoma panel to help identify the specific genetic alterations that are associated with their tumor.

Number Of Genes Tested

21

Sample: Unstained sections from tumor biopsy sample

Turnaround time: 2-3 Weeks

Genes Tested

The table below shows the genes tested by the ForeSENTIA melanoma tumor profile panel, and whether the genes examined are tested for Single Nucleotide Variants, Insertions and Deletions, Copy Number Alterations, Translocations or a combination of variants.

ForeSENTIA Prostate Tumor Profile Panel

Single Nucleotide Variants / Insertions and Deletions Copy Number Alterations Translocations
AKT1, BRAF, CTNBB1, ERBB2, GNA11, GNAQ, KIT, KRAS, MAP2K1, NF1, NRAS, PIK3CA, POLE, PTEN, TP53 ERBB2, KIT, KRAS, MYC, TP53 ALK, BRAF, NTRK1, NTRK2, NTRK3, RET, ROS1

PROSTATE TUMOR PROFILE PANEL

Description

The ForeSENTIA prostate tumor profile panel tests for numerous genetic alterations that are frequently found in prostate tumors. Identifying the genetic alterations that have led to cancer development can empower the healthcare provider with clinically actionable and therapeutic information and allow them to tailor medical treatment to each tumor’s unique characteristics.

Who is this test for?

Any patient diagnosed with prostate cancer can have tumor profile testing with the ForeSENTIA prostate panel to help identify the specific genetic alterations that are associated with their tumor.

Number Of Genes Tested

27

Sample: Unstained sections from tumor biopsy sample

Turnaround time: 2-3 Weeks

Genes Tested

The table below shows the genes tested by the ForeSENTIA prostate tumor profile panel, and whether the genes examined are tested for Single Nucleotide Variants, Insertions and Deletions, Copy Number Alterations, Translocations or a combination of variants.

ForeSENTIA Prostate Tumor Profile Panel

Single Nucleotide Variants / Insertions and Deletions Copy Number Alterations Translocations
AKT1, APC, AR, ATM, BRAF, BRCA1, BRCA2, CTNNB1, FOXA1, NRAS, PALB2, PIK3CA, PIK3CB, POLE, PTEN, SPOP, TP53 AR, ERBB2, FGFR1, FGFR2, FGFR3, MYC, MYCN, PIK3CA, PTEN, RB1, TP53 TMPRSS2

GLIOMA TUMOR PROFILE PANEL

Description

The ForeSENTIA glioma tumor profile panel tests for numerous genetic alterations that are frequently found in gliomas. Identifying the genetic alterations that have led to cancer development can empower the healthcare provider with clinically actionable and therapeutic information and allow them to tailor medical treatment to each tumor’s unique characteristics.

Who is this test for?

Any patient diagnosed with glioma cancer can have tumor profile testing with the ForeSENTIA glioma panel to help identify the specific genetic alterations that are associated with their tumor.

Number Of Genes Tested

22

Sample: Unstained sections from tumor biopsy sample

Turnaround time: 2-3 Weeks

Genes Tested

The table below shows the genes tested by the ForeSENTIA glioma tumor profile panel, and whether the genes examined are tested for Single Nucleotide Variants, Insertions and Deletions, Copy Number Alterations, Translocations or a combination of variants.

ForeSENTIA Glioma Tumor Profile Panel

Single Nucleotide Variants / Insertions and Deletions Copy Number Alterations Translocations
ATRX, BRAF, CIC, CTNNB1, EGFR, FUBP1, H3F3A, IDH1, IDH2, NF1, POLE, TERT, TP53 1p/19q codeletion, CDKN2A, EGFR, MET, MYC, MYCN, PTEN BRAF, FGFR3, NF1, NTRK1, NTRK2, NTRK3

PAN-CANCER TUMOR PROFILE PANEL

Description

The ForeSENTIA pan-cancer tumor profile panel tests for numerous genetic alterations that are frequently found in several cancers. Identifying the genetic alterations that have led to cancer development can empower the healthcare provider with clinically actionable and therapeutic information and allow them to tailor medical treatment to each tumor’s unique characteristics.

Who is this test for?

Any patient diagnosed with cancer can have tumor profile testing with the ForeSENTIA pan-cancer panel to help identify the specific genetic alterations that are associated with their tumor.

Number Of Genes Tested

76

Sample: Unstained sections from tumor biopsy sample

Turnaround time: 2-3 Weeks

Genes Tested

The table below shows the genes tested by the ForeSENTIA pan-cancer tumor profile panel, and whether the genes examined are tested for Single Nucleotide Variants, Insertions and Deletions, Copy Number Alterations, Translocations or a combination of variants.

ForeSENTIA Pan-Cancer Tumor Profile Panel

Single Nucleotide Variants / Insertions and Deletions Copy Number Alterations Translocations
AKT1, ALK, APC, AR, ARAF, ATM, ATRX, BARD1, BRAF, BRCA1,BRCA2, BRIP1, CHEK2, CIC, CTNNB1,DDR2, DICER1, EGFR, ERBB2, ERBB3, ERBB4, ESR1, FBXW7, FOXA1, FOXL2, FUBP1, GATA3,GNA11, GNAQ, GNAS, H3F3A, IDH1, IDH2, JAK2, KEAP1, KIT, KRAS, MAP2K1, MAP3K1, MET, MLH1, MRE11A, MSH2, MSH6, MTOR, NBN, NF1, NRAS, NTRK1, PALB2, PIK3CA, PIK3CB, PMS2, POLE, PTEN, RAD51C, RAD51D, RAF1, RET, RUNX1, SMAD4, SPOP, STK11, TERT, TP53 1p/19q codeletion, AR, CDKN2A, EGFR, ERBB2, ESR1, FGFR1, FGFR2, FGFR3, KIT, KRAS, MET, MYC, MYCN, PIK3CA, PTEN, RB1, TP53 ALK, BRAF, FGFR3, NF1, NTRK1, NTRK2, NTRK3, RET, ROS1, TMPRSS2

THERAPY-ASSOCIATED TUMOR PROFILE PANELS

ForeSENTIA therapy-associated tumor profile panels focus on genes that are frequently involved in several cancer types.

EGFR KRAS+NRAS PIK3CA+AKT1 BRAF IDH1 + IDH2

Approved targeted therapies or ongoing clinical trials are available to treat specific cancer types caused by alterations in these genes.

HOW DO CANCER MUTATIONS DEVELOP?

Mutations (alterations) in our genes can happen in two ways: either we were born with them by inheriting them from our parents (hereditary), or we acquired them during our lives (somatic).

Somatic mutations can develop due to many risk factors such as smoking, high alcohol consumption, viruses such as HPV (human papillomavirus), exposure to mutagenic chemicals, and environmental pollutants. These alterations cannot be passed to our children. It could take years or decades for them to develop into cancer, depending on the mutations and the site they occur in.

KNOW YOUR GENES, KNOW YOUR CHOICES

When it comes to cancer, don’t rely on general statistical data and standardized treatment.

ForeSENTIA can potentially identify the genetic alterations (changes) that led to your tumor, providing useful information to your doctor in guiding your treatment

HOW DOES ForeSENTIA HELP ME?

ForeSENTIA identifies the characteristics that make your tumor unique. By finding the specific alterations involved in the tumor, your treatment could become precise and targeted – raising your chances of benefiting from your therapy.

With ForeSENTIA, your doctor will have reliable and detailed information of your tumor, allowing them to choose the most suitable treatment options, drug therapies and possibly even clinical trials for you, improving your clinical care.

WHY CHOOSE ForeSENTIA?

  • Eligibility for targeted therapies
  • Higher chances of successful treatment
  • Improved prognostic insight
  • Better clinical management
  • Short turn-around time
  • Proven technology

HOW IS ForeSENTIA PERFORMED?

ForeSENTIA uses a sample from the tumor biopsy that has already been performed.

TECHNOLOGY YOU TRUST

TARGETED TECHNOLOGY

By focusing only on the genetic alterations tested, ForeSENTIA is accurate and precise.

HIGH READ DEPTH

ForeSENTIA analyzes the locations of the genetic alterations hundreds of times, making the test more sensitive and reliable.

HOW IS ForeSENTIA ADMINISTERED ?

  • TALK TO YOUR DOCTOR ABOUT THE IDEAL PANEL FOR YOU
  • A SAMPLE FROM YOUR TUMOR BIOPSY WILL BE SENT TO US
  • THE SAMPLE WILL BE ANALYZED IN OUR LABORATORY
  • RESULTS WILL BE SENT TO YOUR DOCTOR IN 2-3 WEEKS

Depending on the panel, guidance on finding information on therapy choices and clinical trials will be provided.

FAQ

  • What is genetic testing?

    Genetic testing identifies changes in the DNA. These changes might determine the health of an individual.

  • What are somatic mutations?

    Somatic mutations, or alterations, are genetic changes in the DNA that happen after a person is born. These are acquired during a person’s lifetime due to risk factors like smoking, high alcohol consumption and environmental pollutants, and are not inherited. People with cancer have cancer-related somatic alterations in the tumor.

  • What is a tumor profile testing and why is it useful?

    The same cancer type can be caused by different genetic alterations. These differences in the genetic profile of tumors account for the variability of symptoms, progress of disease and response to treatment. Tumor profile testing identifies the specific genetic alteration responsible for cancer development in each patient. The information gained by tumor profile testing allows for a more accurate and reliable prognosis, and helps the healthcare provider choose the most appropriate treatment for their patients depending on the tumor’s unique genetic characteristics.

  • Who should have tumor profile testing?

    Any patient diagnosed with cancer can have tumor profile testing to help identify the specific genetic alterations that are associated with it. This information is critical for healthcare providers as it empowers them to provide a more precise clinical management and treatment that is tailored to the patient’s tumor profile and as such has better chances of being beneficial.

  • How can the ForeSENTIA tumor profile panels help?

    The ForeSENTIA tumor profile panels give you the option to analyze a comprehensive list of genetic alterations found in tumor, allowing for the best chance to identify the genetic alterations that caused the cancer. This information will allow the healthcare provider to choose a treatment plan that is expertly fitted to the characteristics of the tumor, identify relevant clinical trials and approved therapies, thus providing the patient with improved prognostic insight and medical management.

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